Only if this is someone you've tried lighter brush offs with, and who remains aggressively confrontational with you.
Really though, even if the guy keeps slinging mud your way, if you can get the other people in a group and get everyone's backs to him (close him out of the circle), or just "whatever, dude" him and walk away, often that's all you've got to do.
Just make the guy feel like the more he does, the more socially retarded he looks. The whole point of needling someone is to try to make yourself look cooler than the person you needle. If your attempts repeatedly backfire and make you look increasingly retarded, you will stop.